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However, their clinical applications face several significant challenges

Individual response varies significantly

158 More severe mutations such as frameshift and nonsense mutations have not been found, indicating that some residual activity is required for survival

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Specifically, the ability of phagocytes to digest bacteria, the ability of lymphocytes to proliferate in response to PHA, the ability of monocytes to develop into mature antigen trained dendritic cells, and the ability of dendritic cell trained lymphocytes to lyse tumor cells were determined ex vivo